Preheat the oven to 375 degrees. Line a baking sheet with parchment paper or a baking mat.
In a mixing bowl, mix together (I find it easiest with gloved hands) the ground turkey, egg, panko, garlic powder, salt, black pepper, and Worcestershire sauce until well combined.
Form the turkey mixture into 2-4 loaf shapes and place on the baking sheet.
In a small bowl, mix together the ketchup, balsamic vinegar, and brown sugar.
Brush half of the ketchup mixture on top of the turkey loaves.
Bake for 15 minutes, brush the remaining ketchup mixture over the top of the turkey loaves, and bake for an additional 5-7 minutes, until the center of the loaves reaches 165 degrees.
Remove from the oven and let rest for 5 minutes before serving.